Protecting young hearts from chemotherapy-related heart problems
Investigating whether giving a medicine before doxorubicin cancer treatment could prevent heart damage.
Targeting a relapse causing protein to treat childhood acute myeloid leukaemia
Investigating how a protein that causes relapse in acute myeloid leukaemia interacts with the genetic code, and whether these interactions could be prevented.
Assessing a potent drug combination to fight Wilms tumour
Using two drugs to prevent an essential Wilms tumour protein interacting with a growth-promoting protein, and testing this treatment in patient samples.
MonoGerm clinical trial – is one chemotherapy medicine safer for germinomas?
Testing whether treatment could be safely reduced for children with germinoma brain tumours
Identifying new treatment options for Burkitt lymphoma that doesn’t respond to treatment
Using Burkitt lymphoma models to find essential survival genes to target for therapy.
Understanding chemotherapy doesn’t work as well for some children with neuroblastoma
Investigating how cancer cells can keep dividing and why this makes it harder to treat.
Discovering what makes teenagers and young adults with soft tissue sarcomas different
Finding the biological differences between teenage and young adult cancers cells compared to older adults.
Finding out how infant leukaemia cells interact with the immune system
Understanding how leukaemia cells enlist immune system cells to help them survive chemotherapy.
Using anti-depressants to improve immunotherapy for neuroblastoma
Using anti-depressants to prevent the body's immune system from fighting immunotherapy treatments.