Targeting a relapse causing protein to treat childhood acute myeloid leukaemia
Investigating how a protein that causes relapse in acute myeloid leukaemia interacts with the genetic code, and whether these interactions could be prevented.
Investigating nanomedicines to make treatment safer for children with cancer
Looking at how nanoparticles could improve drug delivery and reduce toxicity for young cancer patients.
Investigating why some children get leukaemia after treatment for other cancers
Looking at the early stages of leukaemia that develops after treatment for other cancers to find out what changes occur and how to fight it.
Understanding what the red flags are in aggressive neuroblastoma to improve and develop treatments
Finding out which changes to how DNA is read in neuroblastoma can give doctors more information about the cancer, and investigating whether these changes could be stopped through medicines.
Assessing a potent drug combination to fight Wilms tumour
Using two drugs to prevent an essential Wilms tumour protein interacting with a growth-promoting protein, and testing this treatment in patient samples.
Discovering what makes teenagers and young adults with soft tissue sarcomas different
Finding the biological differences between teenage and young adult cancers cells compared to older adults.
Understanding chemotherapy doesn’t work as well for some children with neuroblastoma
Investigating how cancer cells can keep dividing and why this makes it harder to treat.
Identifying new treatment options for Burkitt lymphoma that doesn’t respond to treatment
Using Burkitt lymphoma models to find essential survival genes to target for therapy.
MonoGerm clinical trial – is one chemotherapy medicine safer for germinomas?
Testing whether treatment could be safely reduced for children with germinoma brain tumours